PreScission Protease

Angiotensin I Converting Enzyme (ACE-2), also called ACEH (ACE homologue), is a dimeric, zinc-dependent metalloprotease of the ACE family that also includes somatic and germinal ACE. ACE-2 mRNA is found at high levels in heart, testis, and kidney and at lower levels in a wide variety of tissues. ACE-2 is the SARS-CoV and SARS-CoV2 Spike protein receptor in vivo, functions catalytically as a carboxypeptidase to cleave several substrates including angiotensins I and II, and acts as a partner for B0AT1-family amino acid transporters. Through these functions, ACE-2 has been shown to be involved in several diseases including SARS, COVID19, acute lung injury, heart disease, liver and lung fibrosis, inflammatory lung disease, and cardiopulmonary disease . Full length ACE-2 protein includes an extracellular region composed of a single N-terminal peptidase domain and C-terminal collectrin-like domain (CLD), a transmembrane domain, and a short cytoplasmic tail. The N-terminal peptidase region is required for binding to SARS-CoV and SARS-CoV2 spike proteins, while the CLD contains a region that promotes dimerization and association with amino acid transporters.鼠AFGF与人AFGF具有96％的氨基酸序列身份，因此它在鼠和人AFGF之间表现出相当大的物种交叉反应性。PreScission Protease

Name:AITRL,MouseSynonyms:Activation-inducedTNFRmemberLigand,TNFSF18,GITRL,TL-6Description:Activation-InducibleTNF-RelatedLigand(AITRL),alsoknownasGlucocorticoid-InducedTNF-RelatedLigand(GITRL),belongstothetumornecrosisfactorsuperfamily(TNFSF).AITRLisaTypeIIsingletransmembraneproteinandshareslowconservationwithintheextracellulardomainwithotherTNFSFmembers.AITRLisexpressedonmacrophages,immatureandmaturedendriticcellsandBcells.Itsreceptor,Activation-InducibleTNFRfamilyReceptor(AITR),isexpressedonTlymphocytes,naturalkiller(NK)cells,andantigen-presentingcells.AfterbindingbyAITRL,AITRcanbereleased.AITRactivationincreasesresistancetotumorsandviralinfectionsandisinvolvedinautoimmuneandinflammatoryprocesses.Inaddition,activatedAITRincreasesTCR-inducedTcellproliferationandcytokineproductionandrescuesTcellsandNKcellsfromapoptosis.RecombinantmouseActivation-InducibleTNF-RelatedLigand(rmAITRL)producedinE.Recombinant Human CD99/MIC2 (His Tag)（CDNF）也是一种新型神经营养因子，对多巴胺能神经元的强大活性，与神经胶质细胞系衍生的（GDNF）相当。

透明质酸酶，英文名称Hyaluronidase，一类能够降低体内透明质酸活性的酶的总称，结构上由4个相同亚基构成，每个亚基分子量接近14kDa，该酶是一种糖蛋白，包含5%的甘露糖和2.2%的葡萄糖胺。功能上该酶可随机裂解透明质酸、软骨素和硫酸软骨素中的β-N-乙酰己糖胺-[1→4]糖苷键。常与胶原酶联合使用于降解细胞外基质，从而从组织中分离活细胞。本品来源于牛睾丸，活力值为400–1,000units/mg，合适的pH值为4.5–6.0。产品性质中文别名（ChineseSynonym）玻璃糖醛酸酶；玻璃酸酶英文别名（EnglishSynonym）Hyaluronoglucosaminidase；Hyaluronate4-glycanohydrolaseCAS号（CASNO.）37326-33-3来源（Source）牛睾丸分子量（MolecularWeight）~55kDa类型（Type）I-S外观（Appearance）淡黄色至米黄色至褐色粉末

性能参数表达区间及表达系统（Source）CynomolgusCD27Ligand/CD70ProteinisexpressedfromHEK293withHistagattheN-terminal.ItcontainsGln39-Pro194.[Accession|G7PYU6-1]分子量大小（MolecularWeight）TheproteinhasapredictedMWof18.4kDa.Duetoglycosylation,theproteinmigratesto60-90kDabasedonTris-BisPAGEresult.（Endotoxin）Lessthan1EUperugbytheLALmethod.纯度（Purity）>95%asdeterminedbyTris-BisPAGE活性（Activity）ELISAData:ImmobilizedCynomolgusCD27Ligand,HisTagat2μg/ml(100μl/well)ontheplate.DoseresponsecurveforCynomolgus/RhesusmacaqueCD27,hFcTagwiththeEC50of70.8ng/mldeterminedbyELISA.制剂（Formulation）Lyophilizedfrom0.22μmfilteredsolutioninPBS(pH7.4).Normally8%trehaloseisaddedasprotectantbeforelyophilization.重构方法（Reconstitution）Centrifugetubesbeforeopening.Reconstitutingtoaconcentrationmorethan100μg/mlisrecommended.Dissolvethelyophilizedproteinindistilledwater.成纤维细胞生长因子18（FGF-18）是20 kDa蛋白，在骨骼发育和骨稳态中起着重要作用。

糖苷酶F(PNGaseF)是一种酰胺水解酶，经过和平空间站伊丽莎菌克隆，主要由脑膜炎脓杆菌等革兰氏阴性菌分泌。N-糖苷酶F(PNGaseF)在酵母中重组表达（比活性：100000U/mL），可以裂解由天冬酰胺连接的高甘露糖、杂合和复杂的寡糖糖蛋白。PNGaseF的切割位点为糖蛋白内侧N-乙酰葡萄糖胺（GlcNAc）和天冬酰氨残基之间的酰胺键，同时将酶解后蛋白上的天冬氨酰转化为天冬氨酸。本产品带his标签，常应用于抗体及其相关蛋白完全去糖基化。另外，我司还提供其他类型的糖苷酶，包括酵母重组表达的N-糖苷酶F（比活性：750000U/mL），内切糖苷酶H，内切糖苷酶S。产品信息产品性质中文别名（Chinesesynonym）N-糖酰胺酶F；N-糖苷酶F英文别名（Englishsynonym）PNGaseF来源（Source）酵母重组表达分子量（Molecularweight）36kDa比活性（Specificactivity）100000U/mL缓冲液组分（Buffer）20mMTris-HClpH7.5,50mMNaCl,5mMEDTA,50%Glycerol在分子生物学、生物化学或生物工程制药研究中也常作为工具酶用于重组融合蛋白的特异性断裂。Recombinant Mouse CD55 Protein,His Tag

猴痘病毒（Monkeypox Virus, MPXV）属于正痘病毒属。一般来说，同属病毒具有相似的生物学特性。PreScission Protease

SARS-CoV-2,whichcausestheglobalpandemiccoronavirusdisease2019(Covid-19),belongstoafamilyofvirusesknownascoronaviruses.TheSARS-CoV-2Sproteinisaglycoproteinthatmediatesmembranefusionandviralentry.TheRBDofSARS-CoV-2bindsametallopeptidase,angiotensin-convertingenzyme2(ACE-2).SeveralemergingSARS-CoV-2genomeshavebeenidentifiedincludingtheOmicron,orB.1.1.529,variant.FirstidentifiedinNovember2021inSouthAfrica,theOmicronvariantquicklybecamethepredominantSARS-CoV-2variantandisconsideredavariantofconcern(VOC).TheOmicronvariantcontains15mutationsinRBDdomainthatpotentiallyaffectviralfitnessandtransmissibility.ThemajorityofthemutationsareinvolvedinACE-2bindingandOmicronbindsACE-2withgreateraffinity,potentiallyexplainingitsincreasedtransmissibility.Severalofthesemutationsarealsoidentifiedinfacilitatingimmuneescapeandreducingneutralizationactivitytoseveralmonoclonalantibodies.PreScission Protease

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